The antitumoral compound Kahalalide F acts on cell lysosomes

Cancer Lett. 1996 Jan 19;99(1):43-50. doi: 10.1016/0304-3835(95)04036-6.

Abstract

The target for the antitumoral peptidic drug, Kahalalide F, has been studied in cultured cells. In the presence of the compound, the cells became impressively swollen, showing the formation of large vacuoles. The formation of these vacuoles appears to be the consequence of changes in lysosomal membranes. Thus, lysosomes are a target for Kahalalide F action.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antineoplastic Agents / pharmacology*
  • Cell Division / drug effects
  • Cells, Cultured
  • Chlorocebus aethiops
  • Cricetinae
  • Depsipeptides*
  • Endoplasmic Reticulum / drug effects
  • Golgi Apparatus / drug effects
  • HeLa Cells
  • Humans
  • Kidney / cytology
  • Kidney / drug effects
  • Kidney / ultrastructure
  • Lysosomes / drug effects*
  • Molecular Sequence Data
  • Peptides / pharmacology*
  • Rats
  • Subcellular Fractions / drug effects
  • Vero Cells

Substances

  • Antineoplastic Agents
  • Depsipeptides
  • Peptides
  • kahalalide F