A gas chromatographic method for the estimation of phenprocoumon, 3-(1-phenyl-propyl)-4-hydroxycoumarin (Marcoumar, Liquamar), in human serum or plasma

P J Brombacher; H M Cremers; M J Mol; P H Muijrers; P M Van der Plas; P E Verheesen

doi:10.1016/0009-8981(77)90364-3

A gas chromatographic method for the estimation of phenprocoumon, 3-(1-phenyl-propyl)-4-hydroxycoumarin (Marcoumar, Liquamar), in human serum or plasma

Clin Chim Acta. 1977 Mar 15;75(3):443-8. doi: 10.1016/0009-8981(77)90364-3.

Authors

P J Brombacher, H M Cremers, M J Mol, P H Muijrers, P M Van der Plas, P E Verheesen

PMID: 856495
DOI: 10.1016/0009-8981(77)90364-3

Abstract

A rapid and reliable gas-chromatographic method is described for the estimation of phenprocoumon from human serum or plasma. No interference was found from other usual oral anticoagulant drugs. The method can be used for therapeutic and toxic levels. The appearance of two volatile derivatives of phenprocoumon (in constant ratio) is discussed.

MeSH terms

4-Hydroxycoumarins / blood*
Chromatography, Gas / methods
Humans
Microchemistry
Phenprocoumon / blood*
Plasma

Substances

4-Hydroxycoumarins
Phenprocoumon