Avid In-111 labeled WBC accumulation in a patient with active osteoarthritis of both knees

Clin Nucl Med. 1995 Nov;20(11):973-5. doi: 10.1097/00003072-199511000-00005.


An In-111 WBC study showed intense periarticular uptake in both knees of a patient being investigated to exclude joint infection before total knee replacement surgery for advanced osteoarthritis. Infection was subsequently excluded. Patients with synovitis secondary to active osteoarthritis can have intense synovial uptake of labeled WBCs. This should be considered as a cause of false-positive scans in the investigation of septic arthritis with labeled WBCs.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Arthritis, Infectious / diagnostic imaging
  • Diagnosis, Differential
  • False Positive Reactions
  • Humans
  • Indium Radioisotopes*
  • Knee Joint / diagnostic imaging*
  • Leukocytes
  • Male
  • Osteoarthritis / complications
  • Osteoarthritis / diagnostic imaging*
  • Radionuclide Imaging
  • Synovitis / diagnostic imaging*
  • Synovitis / etiology


  • Indium Radioisotopes