The red cell LW blood group protein is an intercellular adhesion molecule which binds to CD11/CD18 leukocyte integrins

Eur J Immunol. 1995 Dec;25(12):3316-20. doi: 10.1002/eji.1830251217.


Leukocyte adhesion involves the leukocyte-specific integrins CD11a/CD18, CD11b/CD18 and CD11c/CD18, which bind to intercellular adhesion molecules (ICAM). Three ICAM have been described, and are expressed on leukocytes and various other cells, but are absent from red cells. Here, we show that the red cell Landsteiner-Wiener (LW) blood group glycoprotein is an ICAM which binds to the leukocyte-specific integrins. This finding has important implications in red cell physiology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Group Antigens / chemistry*
  • Blood Group Antigens / isolation & purification
  • Blood Group Antigens / metabolism
  • CD11 Antigens / blood*
  • CD18 Antigens / blood*
  • Cell Adhesion Molecules / blood*
  • Cell Adhesion Molecules / chemistry
  • Cell Adhesion Molecules / isolation & purification
  • Erythrocytes / chemistry*
  • Humans
  • Integrins / metabolism*
  • Protein Binding


  • Blood Group Antigens
  • CD11 Antigens
  • CD18 Antigens
  • Cell Adhesion Molecules
  • ICAM4 protein, human
  • Integrins