Parental exposure to hydrocarbons in Prader-Willi syndrome

Dev Med Child Neurol. 1995 Dec;37(12):1101-9. doi: 10.1111/j.1469-8749.1995.tb11971.x.


The purpose of this study was to ascertain whether parental age and parental pre-conceptional exposure to various agents differentiated children with Prader-Willi syndrome (PWS) from obese children without PWS. Two groups of patients under 25 years of age were studied, 15 persons with PWS, and 13 with PWS-like symptoms. In the PWS group deletions were detected on chromosome 15q11-q13 and parents were older. The parents' occupational and recreational exposure to environmental toxins was recorded and correlated to the clinical diagnosis, genetics and behaviour characteristics. Paternal exposure to gasoline/petrol was significantly higher in the PWS group and is suggested as a possible important factor in the aetiology of PWS.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Body Mass Index
  • Child
  • Child, Preschool
  • Chromosome Aberrations
  • Chromosome Deletion
  • Chromosome Disorders
  • Chromosomes, Human, Pair 15
  • Environmental Exposure
  • Female
  • Humans
  • Hydrocarbons / adverse effects*
  • Infant
  • Male
  • Parents*
  • Prader-Willi Syndrome / genetics*


  • Hydrocarbons