Aberrant gene for E1 Tor hemolysin from Vibrio cholerae non-O1, N037

FEMS Microbiol Lett. 1995 Nov 1;133(1-2):151-4. doi: 10.1111/j.1574-6968.1995.tb07876.x.


Vibrio cholerae non-O1 strain N037 produced a hemolysin (NO37-Hly) which was antigenically similar to E1 Tor hemolysin (E1 Tor-Hly) but different in molecular size, hemolytic activity, and glucose binding capacity. In the gene encoding NO37-Hly, a 4-bp insertion into the structural gene for E1 Tor-Hly (hlyA) was found. The insertion in a shift of codon frames generating a new stop codon in the downstream region. NO37-Hly was a truncated product of E1 Tor-Hly sharing 90% of the N terminal region. This suggested that the 10% C-terminal region of E1 Tor-Hly is needed for the maximal hemolytic activity and glucose binding capacity.

MeSH terms

  • Amino Acid Sequence
  • Bacterial Toxins / genetics
  • Base Sequence
  • Cloning, Molecular
  • Genes, Bacterial / genetics
  • Hemolysin Proteins / genetics*
  • Molecular Sequence Data
  • Mutation / genetics
  • Sequence Analysis, DNA
  • Sequence Homology, Nucleic Acid
  • Vibrio cholerae / genetics*


  • Bacterial Toxins
  • Hemolysin Proteins

Associated data

  • GENBANK/D58374