Analysis of Staphylococcus aureus genes encoding penicillin-binding protein 4 and an ABC-type transporter

Gene. 1995 Dec 29;167(1-2):111-3. doi: 10.1016/0378-1119(96)82965-9.


A region of the Staphylococcus aureus chromosome has been isolated that contains the gene encoding penicillin-binding protein 4 (PBP4), as well as abcA, a gene that encodes a protein with strong sequence similarity to the ABC transporter family of proteins. A disruption in abcA by Campbell-type integration results in cells that display an increased resistance to methicillin and cefoxitin, two antibiotics known to interact with low-molecular-weight PBPs. Based on these observations, a potential regulatory link between these two genes is discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • ATP-Binding Cassette Transporters / genetics*
  • Amino Acid Sequence
  • Bacterial Proteins*
  • Base Sequence
  • Carrier Proteins / genetics*
  • Gene Expression Regulation
  • Genes, Bacterial
  • Hexosyltransferases*
  • Molecular Sequence Data
  • Muramoylpentapeptide Carboxypeptidase / genetics*
  • Mutagenesis, Insertional
  • Penicillin-Binding Proteins
  • Peptidyl Transferases*
  • RNA, Messenger / genetics
  • Staphylococcus aureus / genetics*
  • beta-Lactam Resistance


  • ATP-Binding Cassette Transporters
  • Bacterial Proteins
  • Carrier Proteins
  • Penicillin-Binding Proteins
  • RNA, Messenger
  • Peptidyl Transferases
  • Hexosyltransferases
  • Muramoylpentapeptide Carboxypeptidase

Associated data

  • GENBANK/U29454
  • GENBANK/U29478