Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II

Gene. 1995 Dec 29;167(1-2):297-302. doi: 10.1016/0378-1119(95)00634-6.


We report the isolation of a cDNA encoding a new type of transcription factor S-II, termed h-SII-T1, from a human library. The mRNA corresponding to the clone is highly expressed in testis and ovary. Comparison of the deduced amino acid (aa) sequence with those of other S-II molecules shows that (i) the C-terminal zinc finger (Zf) domain is highly conserved, and (ii) the central segment is most similar to that of the rat testis-specific S-II. Further analyses of the hS-II-T1 aa sequence indicate that its N-terminal sequence exhibits similarity to eubacterial sigma 54. The significance of tissue-specific S-II molecules for the regulation of transcription elongation is discussed.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • DNA, Complementary / genetics
  • DNA-Binding Proteins / genetics
  • Female
  • Gene Expression
  • Humans
  • Male
  • Molecular Sequence Data
  • Ovary / chemistry
  • RNA, Messenger / genetics
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Testis / chemistry
  • Tissue Distribution
  • Transcription Factors / genetics*
  • Transcription Factors, General*
  • Transcriptional Elongation Factors*
  • Zinc Fingers


  • DNA, Complementary
  • DNA-Binding Proteins
  • RNA, Messenger
  • Transcription Factors
  • Transcription Factors, General
  • Transcriptional Elongation Factors
  • transcription factor S-II

Associated data

  • GENBANK/D50495