Increased prevalence of atherosclerotic wall changes in patients with hyperlipidaemia after renal transplantation

J Intern Med. 1996 Feb;239(2):177-80.


Objectives: The initial aim of this study was to evaluate the possibility of influencing atherosclerosis in hyperlipidaemic renal transplant patients by lowering blood lipids with gemfibrozil treatment.

Design: Although this double-blind, randomized trial was stopped after 6 months owing to the suspicion of drug interference, we report here on the results of baseline ultrasonographic examinations.

Setting: The outpatient clinic at the Department of Transplantation Surgery, Huddinge University Hospital, Huddinge, Sweden.

Subjects and methods: The carotid arteries were examined in 16 out of the 19 kidney transplant patients included in the study using an ultrasonographic duplex scanner.

Main outcome measures: Plaque occurrence and the common carotid intima-media thickness of the renal transplant recipients were compared to the same parameters in a normotensive control group of approximately the same age from a previous study.

Results: An increased prevalence of plaque (75% of the patients having plaque on one or both sides) was seen in the hyperlipidaemic renal transplant patients in comparison with the control group (16%; P < 0.001). The common carotid intima-media complex was thicker (P < 0.05), and the lumen diameter and the calculated cross-sectional intima-media area were greater (P < 0.01-0.001) in the transplant recipients.

Conclusions: Markedly increased atherosclerotic wall changes are seen in the carotid arteries of patients with hyperlipidaemia after renal transplantation.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Arteriosclerosis / diagnostic imaging
  • Arteriosclerosis / etiology*
  • Carotid Artery, Common / diagnostic imaging
  • Double-Blind Method
  • Female
  • Gemfibrozil / therapeutic use*
  • Humans
  • Hyperlipidemias / complications*
  • Hyperlipidemias / drug therapy*
  • Hypolipidemic Agents / therapeutic use*
  • Kidney Transplantation*
  • Male
  • Middle Aged
  • Prevalence
  • Tunica Intima
  • Tunica Media
  • Ultrasonography


  • Hypolipidemic Agents
  • Gemfibrozil