The role of natural killer cells in immune surveillance of cancer

Curr Opin Immunol. 1995 Oct;7(5):704-10. doi: 10.1016/0952-7915(95)80080-8.


In the past year, a subset of natural killer cells designated 'A-NK cells' has been characterized. These immune cells appear to be able to enter solid tissues, migrate to sites of metastasis and eliminate malignant tissue cells, but spare normal tissue cells. They appear to be ideal surveillance cells, readily capable of upregulating antitumor functions in response to local activation signals.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Killer Cells, Natural / immunology*
  • Killer Cells, Natural / pathology
  • Lymphocyte Activation
  • Neoplasms / immunology*