Integrin transmembrane signaling and cytoskeletal control

Curr Opin Cell Biol. 1995 Oct;7(5):681-9. doi: 10.1016/0955-0674(95)80110-3.


Integrins are remarkably multifunctional: they mediate cell adhesion and migration, orchestrate organization of the actin-based cytoskeleton, and activate signal transduction pathways. Recent studies have identified a variety of steps and hierarchies in these intracellular cytoskeletal and signaling responses, laying the groundwork for future studies on specificity and coordination with responses to growth factors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Adhesion / physiology
  • Cytoskeleton / physiology*
  • Humans
  • Integrins / physiology*
  • Signal Transduction / physiology*


  • Integrins