New insights into the function of collagens from genetic analysis

Curr Opin Cell Biol. 1995 Oct;7(5):720-7. doi: 10.1016/0955-0674(95)80115-4.


Recent studies utilizing transgenic approaches, in combination with mouse and human genetics, are leading to insights into the in vivo functions of fibrillar and non-fibrillar collagens. This information helps define the molecular causes of inherited disorders of connective tissues and provides answers to fundamental questions of tissue and organ morphogenesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Animals, Genetically Modified
  • Collagen / genetics
  • Collagen / metabolism*
  • Extracellular Matrix / metabolism*
  • Gene Expression / genetics
  • Humans
  • Morphogenesis / genetics
  • Mutation


  • Collagen