A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression

Curr Opin Cell Biol. 1995 Oct;7(5):736-47. doi: 10.1016/0955-0674(95)80117-0.


A dynamic and reciprocal flow of information between cells and the extracellular matrix contributes significantly to the regulation of form and function in developing systems. Signals generated by the extracellular matrix do not act in isolation. Instead, they are processed within the context of global signalling hierarchies whose constituent inputs and outputs are constantly modulated by all the factors present in the cell's surrounding microenvironment. This is particularly evident in the mammary gland, where the construction and subsequent destruction of such a hierarchy regulates changes in tissue-specific gene expression, morphogenesis and apoptosis during each developmental cycle of pregnancy, lactation and involution.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Division
  • Extracellular Matrix / genetics
  • Extracellular Matrix / physiology*
  • Female
  • Gene Expression / genetics*
  • Mammary Glands, Animal / growth & development
  • Mammary Glands, Animal / physiology
  • Morphogenesis / genetics
  • Morphogenesis / physiology
  • Pregnancy
  • Signal Transduction / genetics
  • Signal Transduction / physiology*