Chronic arthritis increases tyrosine hydroxylase mRNA levels in the pontine noradrenergic cell groups

H J Cho; H S Lee; M A Bae; K Joo

doi:10.1016/0006-8993(95)00937-l

Chronic arthritis increases tyrosine hydroxylase mRNA levels in the pontine noradrenergic cell groups

Brain Res. 1995 Oct 9;695(1):96-9. doi: 10.1016/0006-8993(95)00937-l.

Authors

H J Cho¹, H S Lee, M A Bae, K Joo

Affiliation

¹ Department of Anatomy, School of Medicine, Kyungpook National University, Dongin Dong, Taegu, South Korea.

PMID: 8574655
DOI: 10.1016/0006-8993(95)00937-l

Abstract

In situ hybridization was used to examine the change of tyrosine hydroxylase(TH) mRNA levels in the pontine noradrenergic cell groups of chronic monoarthritic rats induced by adjuvant inoculation. The number of TH mRNA-expressing neurons and grains per labeled neuron in the A5,A6 and A7 cell groups on the ipsilateral and contralateral sides significantly increased 2 weeks after adjuvant inoculation into the left tibio-tarsal joint, compared to controls. These results suggest that noradrenalin in the pontine region may play a role in modulating chronic nociceptive stimuli.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adrenergic Fibers / metabolism*
Animals
Arthritis, Experimental / metabolism*
Brain Stem / metabolism*
In Situ Hybridization
Male
RNA, Messenger / biosynthesis*
Rats
Rats, Sprague-Dawley
Time Factors
Tyrosine 3-Monooxygenase / metabolism*

Substances

RNA, Messenger
Tyrosine 3-Monooxygenase