Reproduction and caffeine consumption--a literature review

Early Hum Dev. 1995 Aug 30;43(1):1-14. doi: 10.1016/0378-3782(95)01660-u.

Abstract

Caffeine containing drinks are commonly consumed by pregnant women, but definitive studies concerning safety to the fetus are still awaited. This literature review highlights the methodological problems in mounting appropriate studies and assessing those publications that are available. Currently there is little to implicate caffeine consumption with congenital malformations or preterm delivery, but there may be associations with subfertility, miscarriage and intrauterine growth retardation. Definitive prospective studies are required.

Publication types

  • Review

MeSH terms

  • Abnormalities, Drug-Induced / epidemiology
  • Abortion, Spontaneous / chemically induced
  • Abortion, Spontaneous / epidemiology
  • Administration, Oral
  • Animals
  • Caffeine / administration & dosage
  • Caffeine / adverse effects
  • Caffeine / pharmacology*
  • Chick Embryo
  • Female
  • Fetal Growth Retardation / chemically induced
  • Fetal Growth Retardation / epidemiology
  • Humans
  • Incidence
  • Infertility, Female / chemically induced
  • Infertility, Female / epidemiology
  • Obstetric Labor, Premature / chemically induced
  • Obstetric Labor, Premature / epidemiology
  • Pregnancy
  • Prenatal Exposure Delayed Effects
  • Rabbits
  • Rats
  • Reproduction / drug effects*
  • Reproduction / physiology

Substances

  • Caffeine