Recognition and specificity in protein tyrosine kinase-mediated signalling

Trends Biochem Sci. 1995 Nov;20(11):470-5. doi: 10.1016/s0968-0004(00)89103-3.


There are several factors that contribute to the specificities of protein tyrosine kinases (PTKs) in signal transduction pathways. While protein-protein interaction domains, such as the Src homology (SH2 and SH3) domains, regulate the cellular localization of PTKs and their substrates, the specificities of PTKs are ultimately determined by their catalytic domains. The use of peptide libraries has revealed the substrate specificities of SH2 domains and PTK catalytic domains, and has suggested cross-talk between these domains.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Binding Sites
  • Evolution, Molecular
  • Molecular Sequence Data
  • Phosphopeptides / chemistry
  • Phosphopeptides / metabolism
  • Phosphorylation
  • Protein Tyrosine Phosphatases / metabolism
  • Protein-Tyrosine Kinases / metabolism*
  • Signal Transduction*
  • Substrate Specificity
  • src Homology Domains


  • Phosphopeptides
  • Protein-Tyrosine Kinases
  • Protein Tyrosine Phosphatases