Intercellular adhesion molecule-3 on endothelial cells. Expression in tumors but not in inflammatory responses

Am J Pathol. 1996 Feb;148(2):465-72.


Intercellular adhesion molecule-3 (ICAM-3) was identified as the third counter-receptor for lymphocyte function-associated antigen-1. ICAM-3 is absent on endothelial cells in normal tissues but found on endothelial cells in lymphomas. Here, we examined ICAM-3 expression on vascular endothelial cells in lymphomas, nonlymphoid malignancies, benign tumors, and inflammatory diseases. We compared the expression of ICAM-3 on endothelial cells with the severity of inflammatory infiltrates and with the presence of E-selectin and VCAM-1. We found that ICAM-3 expression on endothelial cells was high on both benign and malignant tumors whereas it was low in inflammatory diseases. In contrast to E-selectin, ICAM-3 expression on endothelial cells was not correlated to the severity of inflammatory infiltrates. In hemangiomas, we showed by Northern blot analysis and immunocytochemistry that ICAM-3 expression was induced and that it was localized in immature areas that sustain the early stages of angiogenesis. Therefore, expression of ICAM-3 on blood vessels does not seem to play a role in the recruitment of leukocytes during inflammation but rather is correlated with angiogenesis and tumor development.

MeSH terms

  • Antigens, CD*
  • Antigens, Differentiation*
  • Biomarkers, Tumor
  • Blotting, Northern
  • Cell Adhesion Molecules / analysis
  • Cell Adhesion Molecules / biosynthesis*
  • E-Selectin / analysis
  • E-Selectin / biosynthesis
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / metabolism*
  • Hemangioma / chemistry
  • Hemangioma / metabolism
  • Hodgkin Disease / metabolism
  • Humans
  • Immunoenzyme Techniques
  • Inflammation / metabolism*
  • Lymphoid Tissue / metabolism
  • Lymphoma / chemistry
  • Lymphoma / metabolism*
  • Lymphoma, Non-Hodgkin / metabolism
  • Neoplasms / metabolism*
  • Neovascularization, Pathologic / physiopathology
  • Vascular Cell Adhesion Molecule-1 / analysis
  • Vascular Cell Adhesion Molecule-1 / biosynthesis


  • Antigens, CD
  • Antigens, Differentiation
  • Biomarkers, Tumor
  • Cell Adhesion Molecules
  • E-Selectin
  • ICAM3 protein, human
  • Vascular Cell Adhesion Molecule-1