Myopathy and HIV infection

Curr Opin Rheumatol. 1995 Nov;7(6):497-502. doi: 10.1097/00002281-199511000-00006.


Skeletal muscle involvement may occur at all stages of HIV infection. The most simple classification of muscular disorders in HIV-infected patients is 1) HIV-associated myopathies, 2) zidovudine myopathy, 3) HIV wasting syndrome, and 4) opportunistic infections and tumoral infiltrations of muscle. Immunohistology for major histocompatibility complex class I antigen and histochemical reaction for cytochrome c oxidase are helpful in correctly classifying a myopathy as HIV polymyositis or zidovudine myopathy. Studies of cytokine expression in HIV-infected patients and of supplementation with compounds such as carnitine or micronutrients such as selenium might yield new insights into the pathogenesis and treatment of the various AIDS-associated muscular disorders.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • AIDS-Related Opportunistic Infections / complications*
  • AIDS-Related Opportunistic Infections / diagnosis
  • Animals
  • HIV Infections / complications*
  • HIV Infections / diagnosis
  • HIV Infections / virology
  • Humans
  • Muscular Diseases / diagnosis
  • Muscular Diseases / virology*