Effect of rifampin on Staphylococcus aureus colonization in children on chronic peritoneal dialysis

Pediatr Nephrol. 1995 Oct;9(5):609-11. doi: 10.1007/BF00860952.


The efficacy of rifampin in eliminating Staphylococcus aureus colonization was evaluated in a pediatric peritoneal dialysis population. Six children with documented nasal colonization were treated for 7 days with rifampin and cloxacillin. Although antimicrobial therapy eliminated nasal carriage in all patients, recolonization occurred in 66%. Exit site colonization proved difficult to eradicate with negative cultures documented in only 3 of 5 children after rifampin/cloxacillin therapy. Although S. aureus carriage is a risk factor for S. aureus infections, efforts to eradicate carriage with rifampin are hindered by rapid recolonization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibiotics, Antitubercular / therapeutic use*
  • Catheters, Indwelling / microbiology*
  • Child
  • Cloxacillin / therapeutic use
  • Colony Count, Microbial
  • Drug Resistance, Microbial
  • Drug Therapy, Combination / therapeutic use
  • Female
  • Humans
  • Male
  • Nose / microbiology*
  • Penicillins / therapeutic use
  • Peritoneal Dialysis, Continuous Ambulatory / adverse effects*
  • Peritoneal Dialysis, Continuous Ambulatory / instrumentation
  • Peritonitis / drug therapy
  • Peritonitis / microbiology*
  • Rifampin / therapeutic use*
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / isolation & purification


  • Antibiotics, Antitubercular
  • Penicillins
  • Cloxacillin
  • Rifampin