In order to study the efficacy of early chemotherapy after operation of gastric cancer, 84 cases of gastric cancer were divided randomly into two groups. The treated group received both Chinese medicinal herbs and chemotherapy on the first postoperational day and the control group were treated routinely in the same way two weeks later. The results showed that complications of incision and anastomoses of the treated group did not rise and all kinds of blood cells reduce in comparison with those of control group (P > 0.05). Meanwhile, nutritious condition of the treated group was improved significantly as compared with that of control group (P < 0.05) because of use of Chinese medicinal herbs and nutrition support. This study suggested that chemotherapy could be used early after operation of gastric cancer in combination with Chinese medicinal herbs.