Biochemical and functional diversity of microtubule motors in the nervous system

Curr Opin Neurobiol. 1995 Oct;5(5):551-8. doi: 10.1016/0959-4388(95)80058-1.

Abstract

The fact that multiple microtubule-based motors exist in brain inevitably raises questions about their function. Transcripts for at least seven kinesin superfamily genes and even more dynein heavy chain genes have been detected in brain cDNA libraries. The challenge now is to match their gene products to specific functions in cells of the nervous system. Recent studies have attempted to establish a function for each microtubule motor by using recombinant protein and immunochemical approaches.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Dynamins
  • GTP Phosphohydrolases / metabolism*
  • Kinesin / metabolism*
  • Microtubules / metabolism*
  • Nervous System Physiological Phenomena*

Substances

  • GTP Phosphohydrolases
  • Kinesin
  • Dynamins