Myelin-associated glycoprotein: a role in myelination and in the inhibition of axonal regeneration?

Curr Opin Neurobiol. 1995 Oct;5(5):588-95. doi: 10.1016/0959-4388(95)80063-8.


Inhibitory molecules in CNS myelin affect axonal regeneration after injury. In the past year, myelin-associated glycoprotein (MAG), a well-characterized myelin protein, has been identified as an inhibitor of axonal regeneration. This finding, together with its established ability to promote outgrowth, defines MAG as a bifunctional molecule. MAG has also been included in a family of sialic acid binding proteins, providing a clue to the identity of the MAG receptor. MAG knockout mice reveal that MAG is not essential for the initiation of myelination; however, it plays an important role in maintaining a stable interaction between axons and myelin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Axons / physiology*
  • Models, Neurological
  • Myelin Sheath / physiology*
  • Myelin-Associated Glycoprotein / physiology*
  • Nerve Regeneration / physiology*


  • Myelin-Associated Glycoprotein