The basement membrane at the neuromuscular junction: a synaptic mediatrix

Curr Opin Neurobiol. 1995 Oct;5(5):596-605. doi: 10.1016/0959-4388(95)80064-6.


The basement membrane at the neuromuscular junction directs formation of pre- and postsynaptic elements at this synapse. Efforts to understand the molecular basis for development of the postsynaptic specialization have brought new insights into extracellular matrix proteins and their cell-surface receptors. Recent evidence for an agrin receptor and mice null for the s-laminin gene have reinforced the function of the basement membrane in both orthograde and retrograde signalling across the synapse.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Agrin / physiology
  • Animals
  • Basement Membrane / physiology*
  • Laminin / metabolism
  • Mice
  • Models, Neurological
  • Neuromuscular Junction / physiology*
  • Presynaptic Terminals / physiology*


  • Agrin
  • Laminin