Alternative triggering molecules and single chain bispecific antibodies

J Hematother. 1995 Oct;4(5):377-82. doi: 10.1089/scd.1.1995.4.377.

Abstract

Although T cell receptors and Fc receptors are the best known cytotoxic triggering molecules, a number of adhesion molecules recently have been identified as alternative triggering molecules. We discuss how CD44, an adhesion molecule found on all leukocytes and many other cell types, becomes a triggering molecule on NK cells following stimulation with IL-2. We also describe a genetically engineered single chain bispecific antibody, produced in mammalian cells and in bacteria, that is capable of redirecting lysis in the nanogram per milliliter range.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies, Bispecific / immunology*
  • Antibody-Dependent Cell Cytotoxicity
  • CD56 Antigen / analysis
  • Cytotoxicity, Immunologic / immunology*
  • Hyaluronan Receptors / chemistry
  • Hyaluronan Receptors / immunology*
  • Immunoglobulin Variable Region / immunology*
  • Interleukin-2 / pharmacology*
  • Killer Cells, Natural / drug effects
  • Killer Cells, Natural / immunology*
  • Lymphoma / pathology
  • Mice
  • Protein Engineering
  • Recombinant Fusion Proteins / immunology
  • T-Lymphocytes, Cytotoxic / immunology*
  • Trinitrobenzenes / immunology
  • Tumor Cells, Cultured

Substances

  • Antibodies, Bispecific
  • CD56 Antigen
  • Hyaluronan Receptors
  • Immunoglobulin Variable Region
  • Interleukin-2
  • Recombinant Fusion Proteins
  • Trinitrobenzenes