Abstract
In order to obtain rigidity within the sugar moiety of nucleosides, some bicyclic pyrimidine nucleoside analogues were synthesized starting from cyclopentanone. The C-3' is fused to C-4' via a propylene linker in order to obtain a [3.3.0]-bicyclic ring system wherein the sugar moiety should be restricted to mainly the C-1'-exo conformation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / chemical synthesis
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Antiviral Agents / chemistry*
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Antiviral Agents / pharmacology
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Chromatography
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Cyclopentanes / chemistry*
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Cytidine / chemistry
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HIV-1 / drug effects
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HIV-1 / enzymology
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Humans
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Pyrimidines / chemistry*
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Reverse Transcriptase Inhibitors / pharmacology
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Software
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Structure-Activity Relationship
Substances
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Antiviral Agents
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Cyclopentanes
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Pyrimidines
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Reverse Transcriptase Inhibitors
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Cytidine
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pyrimidine