Circadian variation of blood-pressure

Lancet. 1978 Apr 15;1(8068):795-7. doi: 10.1016/s0140-6736(78)92998-7.


Continuous intra-arterial blood-pressure and electrocardiogram recordings were obtained in twenty hypertensive and five normotensive ambulant patients. Blood-pressure was highest mid-morning and then fell progressively throughout the remainder of the day. Blood-pressure was lowest at 3 A.M. and began to rise again during the early hours of the morning before waking. These findings may have important consequences with regard to the therapeutic management of hypertension.

MeSH terms

  • Adult
  • Aged
  • Blood Pressure*
  • Circadian Rhythm*
  • Female
  • Heart Rate
  • Humans
  • Hypertension / physiopathology*
  • Male
  • Middle Aged
  • Sex Factors