Biocompatibility of biodegradable and nonbiodegradable polymer-coated stents implanted in porcine peripheral arteries

Cardiovasc Intervent Radiol. 1995 Jul-Aug;18(4):227-32. doi: 10.1007/BF00239417.


Purpose: To investigate the neointimal response to poly(organo)phosphazene- and amphiphilic polyurethane-coated, oversized, stainless steel stents implanted in porcine peripheral arteries.

Methods: Nonarticulated, stainless steel, slotted-tube stents were coated with 1) a biodegradable poly-(organo)phosphazene with aminoacid ester side groups and 2) a biostable polyurethane prepared from an amphiphilic polyether, diphenyl methane-4,4'-diisocyanate and butane diol as chain extender. The stents were deployed in porcine peripheral arteries using an oversized balloon.

Results: The neonintimal response to amphiphilic polyurethane-coated stents was similar to the uncoated metallic stents. Poly(organo)phosphazene-coated stents, however, induced a severe histiolymphocytic and fibromuscular reaction resembling a foreign body reaction.

Conclusions: Amphiphilic polyurethane is very promising as a biocompatible stent coating. Poly-(organo)phosphazene, however, appears unsuitable for this purpose.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angioplasty, Balloon
  • Animals
  • Biocompatible Materials* / chemistry
  • Biodegradation, Environmental*
  • Butylene Glycols / chemistry
  • Female
  • Foreign-Body Reaction / pathology
  • Histiocytes / pathology
  • Iliac Artery / diagnostic imaging
  • Iliac Artery / injuries
  • Iliac Artery / pathology*
  • Isocyanates / chemistry
  • Lymphocytes / pathology
  • Male
  • Organophosphorus Compounds / chemistry
  • Polymers* / chemistry
  • Polyurethanes / chemistry
  • Radiography
  • Stainless Steel
  • Stents*
  • Surface Properties
  • Swine
  • Tunica Intima / pathology


  • Biocompatible Materials
  • Butylene Glycols
  • Isocyanates
  • Organophosphorus Compounds
  • Polymers
  • Polyurethanes
  • Stainless Steel
  • 4,4'-diphenylmethane diisocyanate