Monoclonal lymphocyte proliferation and bcl-2 rearrangement in essential mixed cryoglobulinaemia

Eur J Clin Invest. 1995 Nov;25(11):833-7. doi: 10.1111/j.1365-2362.1995.tb01692.x.


A patient with essential mixed cryoglobulinaemia (EMC) type II and hepatitis C virus (HCV) infection, in whom immunophenotypic and genotypic studies demonstrated a clonal proliferation of B lymphocytes, is described. Fluorescent in situ hybridization with probes to Ig heavy chain gene and to the oncogene bcl-2 demonstrated a translocation of bcl-2 to the immunoglobulin heavy chain locus on chromosome 14. A sharp rise in the level of the monoclonal IgM was associated with a second genetic aberration [t(8:22) (q24:q11)]. No other clinical evidence of disease progression could be demonstrated. Low grade lymphoproliferative disorder with typical cytogenetic abnormalities developed on the background of EMC and HCV. Clinical progression was associated with a second genetic abnormality involving the myc oncogene. It is possible that HCV chronic infection may indirectly influence oncogenes associated with lymphoma.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • B-Lymphocytes / pathology*
  • Blotting, Southern
  • Cell Division
  • Cryoglobulinemia / complications
  • Cryoglobulinemia / genetics*
  • Cryoglobulinemia / immunology
  • Cryoglobulinemia / pathology*
  • Female
  • Gene Rearrangement*
  • Genes, Immunoglobulin*
  • Hepacivirus
  • Hepatitis C / complications
  • Humans
  • Immunoglobulin Heavy Chains / genetics
  • Immunoglobulin M / blood
  • In Situ Hybridization, Fluorescence
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins c-bcl-2
  • Proto-Oncogenes / genetics*
  • Translocation, Genetic


  • Immunoglobulin Heavy Chains
  • Immunoglobulin M
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-bcl-2