Tocotrienols from palm oil as potent inhibitors of lipid peroxidation and protein oxidation in rat brain mitochondria

Neurosci Lett. 1995 Aug 11;195(3):179-82. doi: 10.1016/0304-3940(95)11812-b.


The tocotrienol-rich-fraction (TRF) from palm oil, being tried as a more economical and efficient substitute for alpha-tocopherol, significantly inhibited oxidative damage in vitro to both lipids and proteins in rat brain mitochondria induced by ascorbate-Fe2+, the free radical initiator azobis(2-amidopropane)dihydrochloride (AAPH) and photosensitisation. The observed inhibitory effect was both time- and concentration-dependent. At a low concentration of 5 microM, TRF can significantly inhibit oxidative damage to both lipids and proteins. The inhibitory effect of TRF seems to be mainly due to gamma-tocotrienol and to a lesser extent alpha- and delta-tocotrienols. TRF was significantly more effective than alpha-tocopherol. This fraction from palm oil can be considered a natural antioxidant supplement capable of protecting the brain against oxidative damage and thereby from the ensuing adverse alterations.

MeSH terms

  • Animals
  • Antioxidants / pharmacology*
  • Brain / metabolism
  • Brain / ultrastructure*
  • Dietary Fats, Unsaturated / pharmacology
  • Female
  • Lipid Peroxidation / drug effects*
  • Mitochondria / metabolism*
  • Oxidation-Reduction / drug effects
  • Palm Oil
  • Plant Oils / pharmacology
  • Proteins / metabolism
  • Rats
  • Rats, Wistar
  • Tocotrienols
  • Vitamin E / analogs & derivatives*
  • Vitamin E / pharmacology


  • Antioxidants
  • Dietary Fats, Unsaturated
  • Plant Oils
  • Proteins
  • Tocotrienols
  • Vitamin E
  • Palm Oil
  • tocotrienol, alpha