Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Feb 16;271(5251):994-6.
doi: 10.1126/science.271.5251.994.

Phenotypes of Mouse Diabetes and Rat Fatty Due to Mutations in the OB (Leptin) Receptor

Affiliations

Phenotypes of Mouse Diabetes and Rat Fatty Due to Mutations in the OB (Leptin) Receptor

S C Chua Jr et al. Science. .

Abstract

Mice harboring mutations in the obese (ob) and diabetes (db) genes display similar phenotypes, and it has been proposed that these genes encode the ligand and receptor, respectively, for a physiologic pathway that regulates body weight. The cloning of ob, and the demonstration that it encodes a secreted protein (leptin) that binds specifically to a receptor (OB-R) in the brain, have validated critical aspects of this hypothesis. Here it is shown by genetic mapping and genomic analysis that mouse db, rat fatty (a homolog of db), and the gene encoding the OB-R are the same gene.

Comment in

Similar articles

See all similar articles

Cited by 246 articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback