Retinoic acid and pattern formation in vertebrates

Trends Genet. 1995 Aug;11(8):314-9. doi: 10.1016/s0168-9525(00)89089-7.


Retinoic acid has spectacular teratogenic effects on the development of vertebrate embryos, but whether this has significance for the normal mechanisms of development remains an open question. Recent results from the analyses of Hox gene regulation and the phenotypes of mice mutant for the components of the retinoid signaling pathway suggest that retinoic acid is involved in the genesis of pattern in vivo.

Publication types

  • Review

MeSH terms

  • Animals
  • Embryonic and Fetal Development / genetics
  • Genes, Homeobox / drug effects
  • Mice
  • Tretinoin / metabolism*
  • Tretinoin / pharmacology*
  • Vertebrates / embryology*
  • Vertebrates / genetics*


  • Tretinoin