Parieto-occipital hypoperfusion in late whiplash syndrome: first quantitative SPET study using technetium-99m bicisate (ECD)

Eur J Nucl Med. 1996 Jan;23(1):72-4. doi: 10.1007/BF01736993.


Brain single-photon emission tomography (SPET) with N,N''-1,2-ethylene-diylbis-L-cysteine diethyl ester dihydrochloride (ECD) was performed on ten patients with a clinically high grade late whiplash syndrome and on 11 controls. Two independent readers blinded to the clinical diagnosis were able to separate the ten patients from normal controls. All these patients had qualitative bilateral parieto-occipital hypoperfusion. To confirm this, the perfusion rate of parieto-occipital over global (perfusion index) was calculated after drawing elliptical regions of interest in transversal-oblique slices. The perfusion indices in patients were significantly lower than in controls as tested by the Mann-Whitney U test. This quantitative study proves our recent qualitatively analysed observation (Lancet 1995; 345: 1513- 1514).

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Case-Control Studies
  • Cerebrovascular Circulation
  • Cysteine* / analogs & derivatives*
  • Humans
  • Occipital Lobe / diagnostic imaging*
  • Organotechnetium Compounds*
  • Parietal Lobe / diagnostic imaging*
  • Time Factors
  • Tomography, Emission-Computed, Single-Photon*
  • Whiplash Injuries / diagnostic imaging*
  • Whiplash Injuries / physiopathology


  • Organotechnetium Compounds
  • technetium Tc 99m bicisate
  • Cysteine