Cloning and characterization of a novel zinc finger gene in Xp11.2

Genomics. 1995 Nov 20;30(2):361-5. doi: 10.1006/geno.1995.0031.


During a systematic search for open reading frames in chromosome band Xp11.2, a novel gene (ZNF157) that encodes a putative 506-amino-acid protein with the sequence characteristics of a zinc-finger-containing transcription factor was isolated. ZNF157 is encoded by four exons distributed over > 20 kb of genomic DNA. The second and third exons contain sequences similar to those of the previously described KRAB-A and KRAB-B domains, motifs that have been shown to mediate transcriptional repression in other members of the protein family. A fourth exon contains 12 zinc finger DNA binding motifs and finger linking regions characteristic of ZNF proteins of the Krüppel family. ZNF157 maps to the telomeric end of a cluster of ZNF genes that includes ZNF21, ZNF41, and ZNF81.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cloning, Molecular
  • DNA, Complementary
  • Exons
  • Humans
  • Introns
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid
  • X Chromosome*
  • Zinc Fingers / genetics*


  • DNA, Complementary

Associated data

  • GENBANK/U28687