Polymorphisms within the atrial natriuretic peptide gene in essential hypertension

J Hypertens. 1995 Sep;13(9):953-5. doi: 10.1097/00004872-199509000-00003.


Objective: To investigate polymorphisms in the atrial natriuretic peptide gene of African Americans at intron two (Hpall) and exon three (Scal).

Results: The allele frequency of the Hpall mutation was 25% in the hypertensive group (n =60) compared with only 3.4% in normotensive individuals (n = 44, P < 0.0001). The genotype heterozygote for the present mutation was much more common among those with hypertension (50 versus 6.8%, P < 0.0001). The groups were no different for the Scal site alone, although the two mutations were present together more often in the hypertensive group. The Hpall mutation was associated with hypertension in this typically salt-sensitive population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • African Continental Ancestry Group / genetics*
  • Aged
  • Atrial Natriuretic Factor / genetics*
  • Exons
  • Female
  • Genotype
  • Humans
  • Hypertension / ethnology
  • Hypertension / genetics*
  • Hypertension / metabolism
  • Introns
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*


  • Atrial Natriuretic Factor