High-intensity focused ultrasound (HIFU) in the treatment of benign prostatic hyperplasia (BPH)

Keio J Med. 1995 Dec;44(4):146-9. doi: 10.2302/kjm.44.146.


Transurethral resection of the prostate (TURP) and open adenectomy are regarded the golden standard in the management of patients with symptomatic benign prostatic hyperplasia (BPH). Various alternative treatment forms (microwaves, laser, radiofrequency, focused ultrasound) have been introduced recently. They all aim at reduction of morbidity related to TURP keeping a comparable efficacy at the same time. Since December 1992, 50 patients with BPH have been treated by high intensity focused ultrasound (HIFU-P) at our department. Six weeks following HIFU-P mean Qmax improved from 5.7 ml/s to 11.6 ml/s. Post voiding residual volume (RV) dropped from 215 ml to 100 ml, the International Prostate Symptom Score (IPSS) from 19.8 to 9.9. Both, IPSS and RV further improved during the following weeks. Follow-up data one year after treatment demonstrate that results remained stable in the majority of patients. Urinary tract infections were observed in 3 patients, macrohematospermia in all and macrohematuria (caused by the suprapubic catheter) requiring blood transfusion in 1 patient.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Anesthesia, General
  • Anesthesia, Spinal
  • Genitalia, Male / physiopathology
  • Humans
  • Male
  • Middle Aged
  • Prostatic Hyperplasia / physiopathology
  • Prostatic Hyperplasia / therapy*
  • Ultrasonic Therapy / adverse effects
  • Ultrasonic Therapy / instrumentation
  • Ultrasonic Therapy / methods*
  • Urination