Abstract
1. The efficacy of HI-6 and obidoxime in combination with atropine on cyclohexyl methylphosphonofluoridate (GF)-induced cholinergic and stressogenic effects in rats was studied. 2. HI-6 sufficiently reactivated cholinesterase activity in blood as well as acetylcholinesterase activity in brain and diaphragm following GF intoxication, and practically eliminated stressogenic effects of GF (an increase in plasma corticosterone level and liver tyrosine aminotransferase activity). 3. Obidoxime had practically no effect on enzyme activity or stressogenic effects of GF agent. 4. These findings confirm that HI-6 has definite advantages over obidoxime in the treatment of intoxication with GF.
MeSH terms
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Acetylcholinesterase / metabolism
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Animals
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Atropine / administration & dosage
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Atropine / pharmacology
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Brain / drug effects
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Brain / enzymology
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Chemical Warfare Agents / toxicity*
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Cholinesterase Inhibitors / administration & dosage
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Cholinesterase Inhibitors / toxicity*
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Cholinesterase Reactivators / administration & dosage
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Cholinesterase Reactivators / pharmacology*
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Cholinesterases / blood
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Corticosterone / blood
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Diaphragm / drug effects
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Diaphragm / enzymology
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Drug Interactions
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Liver / drug effects
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Liver / enzymology
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Male
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Obidoxime Chloride / administration & dosage
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Obidoxime Chloride / pharmacology*
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Organophosphorus Compounds / administration & dosage
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Organophosphorus Compounds / toxicity*
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Oximes
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Pyridinium Compounds / administration & dosage
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Pyridinium Compounds / pharmacology*
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Rats
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Rats, Wistar
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Tyrosine Transaminase / metabolism
Substances
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Chemical Warfare Agents
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Cholinesterase Inhibitors
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Cholinesterase Reactivators
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Organophosphorus Compounds
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Oximes
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Pyridinium Compounds
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Obidoxime Chloride
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Atropine
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Tyrosine Transaminase
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Acetylcholinesterase
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Cholinesterases
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asoxime chloride
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cyclohexyl methylphosphonofluoridate
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Corticosterone