Spectrum of 2,836 cases of invasive bacterial or fungal infections in children: results of prospective nationwide five-year surveillance in Finland. Finnish Pediatric Invasive Infection Study Group

Clin Infect Dis. 1995 Nov;21(5):1134-44. doi: 10.1093/clinids/21.5.1134.

Abstract

In a prospective nationwide laboratory-based surveillance study of all invasive bacterial and fungal infections among children < 16 years of age, 2,836 clinical cases were registered during the 5-year period 1985-1989. Of these cases, 136 were polymicrobial. During the study period, nationwide administration of Haemophilus influenzae type b conjugate vaccine reduced the incidence rates of invasive infection caused by this organism. The most common clinical diagnosis (48% of cases) was bacteremia without an identified focus of infection. The age-specific annual incidence rates of all invasive infections in children < or = 15 years of age, in children < or = 4 years of age, in children < or = 1 year of age, and in children < or = 28 days of age were 55.8, 141.4, 272.7, and 2,749.0 cases/100,000 person-years, respectively. Thirty percent of the children in the study had an underlying condition predisposing to infection. The case-fatality rate was 4.1% for all cases of invasive infection.

MeSH terms

  • Adolescent
  • Age Distribution
  • Bacteremia / epidemiology
  • Bacterial Infections / epidemiology*
  • Bacterial Infections / mortality
  • Child
  • Child, Preschool
  • Enterobacteriaceae Infections / epidemiology
  • Finland / epidemiology
  • Haemophilus Infections / epidemiology
  • Haemophilus Infections / prevention & control
  • Haemophilus Vaccines / pharmacology
  • Haemophilus influenzae
  • Humans
  • Infant
  • Infant, Newborn
  • Mycoses / epidemiology*
  • Mycoses / mortality
  • Prospective Studies
  • Staphylococcal Infections / epidemiology
  • Streptococcal Infections / epidemiology

Substances

  • Haemophilus Vaccines