PCD/DCoH: more than a second molecular saddle

Structure. 1995 Jun 15;3(6):531-4. doi: 10.1016/S0969-2126(01)00186-1.

Abstract

Two recent crystal structures of the tetrameric pterin-4 alpha-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF-1 (DCoH) protein provide fresh insights into how this multifunctional enzyme/transcriptional coactivator works.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / chemistry
  • Hepatocyte Nuclear Factor 1
  • Hepatocyte Nuclear Factor 1-beta
  • Hydro-Lyases / chemistry*
  • Hydro-Lyases / metabolism*
  • Nuclear Proteins / chemistry
  • Protein Conformation
  • Transcription Factors / chemistry
  • Transcription Factors / metabolism

Substances

  • DNA-Binding Proteins
  • Nuclear Proteins
  • Transcription Factors
  • Hepatocyte Nuclear Factor 1
  • Hepatocyte Nuclear Factor 1-beta
  • Hydro-Lyases
  • pterin-4a-carbinolamine dehydratase