Progesterone-induced DNA polymerase activity in full-grown oocytes of Xenopus laevis (1)

J Exp Zool. 1977 Apr;200(1):143-8. doi: 10.1002/jez.1402000117.


DNA polymerase activity increases in full-grown oocytes of Xenopus laevis during in vitro progesterone-induced maturation. This increase is inhibited by cycloheximide. The presence of the oocyte's nucleus (germinal vesicle) seems essential for the induction of this increase: in previously enucleated oocytes, the level of DNA polymerase activity does not change during progesterone treatment. Furthermore, a new form of DNA polymerase is detectable by DEAE chromatography in in vitro matured oocytes.

MeSH terms

  • Animals
  • Cycloheximide / pharmacology
  • DNA-Directed DNA Polymerase / metabolism*
  • Female
  • Isoenzymes / metabolism
  • Oocytes / drug effects
  • Oocytes / enzymology*
  • Ovum / enzymology*
  • Progesterone / pharmacology*
  • Time Factors
  • Xenopus / metabolism*


  • Isoenzymes
  • Progesterone
  • Cycloheximide
  • DNA-Directed DNA Polymerase