Lipopolysaccharide and interleukin-1 depress food-motivated behavior in mice by a vagal-mediated mechanism

Brain Behav Immun. 1995 Sep;9(3):242-6. doi: 10.1006/brbi.1995.1023.


In order to assess the role of vagal nerve afferents in the decrease in food-motivated behavior induced by proinflammatory cytokines, the effects of lipopolysaccharide (LPS, 400 micrograms/kg ip) and recombinant human interleukin-1 beta (IL-1, 750-1500 ng/mouse ip) were tested on nose poke for food in vagotomized and sham-operated mice. Subdiaphragmatic vagotomy attenuated the decrease in response rate induced by IL-1 and LPS. These results suggest that the peripheral immune message is transmitted to the brain via a neural rather than a humoral pathway.

MeSH terms

  • Animals
  • Endotoxins / pharmacology*
  • Feeding Behavior*
  • Humans
  • Interleukin-1 / pharmacology*
  • Lipopolysaccharides / pharmacology*
  • Male
  • Mice
  • Mice, Inbred ICR
  • Motivation*
  • Vagotomy
  • Vagus Nerve / physiology*


  • Endotoxins
  • Interleukin-1
  • Lipopolysaccharides
  • endotoxin, Escherichia coli