Agastaquinone, a new cytotoxic diterpenoid quinone from Agastache rugosa

H K Lee; S R Oh; J I Kim; J W Kim; C O Lee

doi:10.1021/np50125a011

Agastaquinone, a new cytotoxic diterpenoid quinone from Agastache rugosa

J Nat Prod. 1995 Nov;58(11):1718-21. doi: 10.1021/np50125a011.

Authors

H K Lee¹, S R Oh, J I Kim, J W Kim, C O Lee

Affiliation

¹ Korea Research Institute of Bioscience and Biotechnology, KIST, Taejon, Korea.

PMID: 8594148
DOI: 10.1021/np50125a011

Abstract

A new diterpenoid quinone, agastaquinone [1], was isolated from the roots of Agastache rugosa. An oxime derivative [2] of agastaquinone was prepared with hydroxylamine hydrochloride. The structure of agastaquinone [1] was established as 7-hydroxy-12-methoxy-20-norabieta-1,5(10),6,8,12-pentaene-3,11,14- trione by spectroscopic techniques. Compounds 1 and 2 showed nonspecific cytotoxic activities against several human cancer cell lines in vitro (A549, SK-OV-3, SK-MEL-2, XF498, and HCT15).

MeSH terms

Abietanes*
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Diterpenes / chemistry
Diterpenes / isolation & purification*
Diterpenes / pharmacology
Drug Screening Assays, Antitumor
Drugs, Chinese Herbal / chemistry
Drugs, Chinese Herbal / isolation & purification*
Drugs, Chinese Herbal / pharmacology
Humans
Magnetic Resonance Spectroscopy
Plant Roots / chemistry*
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Tumor Cells, Cultured

Substances

Abietanes
Antineoplastic Agents, Phytogenic
Diterpenes
Drugs, Chinese Herbal
agastaquinone