The neurochemical and metabolic cascade following brain injury: moving from animal models to man

J Neurotrauma. 1995 Oct;12(5):903-6. doi: 10.1089/neu.1995.12.903.


Experimental traumatic brain injury produces a series of cellular events contributing to a neurochemical and neurometabolic cascade. This cascade is defined by the release of neurotransmitters resulting in a massive ionic flux, which, consequently, produces an increase in glycolysis. This increase in glycolysis is followed by a metabolic diaschisis, which is related to the degree and extent of behavioral deficits. Clinical efforts have now determined that a similar cascade occurs in human head injury, validating the animal model as well as providing new assessment strategies for the management and treatment of brain injury.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Brain / metabolism*
  • Brain Injuries / metabolism*
  • Disease Models, Animal
  • Glycolysis
  • Humans
  • Male
  • Neurotransmitter Agents / metabolism
  • Species Specificity


  • Neurotransmitter Agents