Effect of the paclitaxel vehicle, Cremophor EL, on the pharmacokinetics of doxorubicin and doxorubicinol in mice

Br J Cancer. 1996 Feb;73(4):522-4. doi: 10.1038/bjc.1996.90.


The effect of the paclitaxel vehicle Cremophor on the pharmacokinetics of doxorubicin and doxorubicinol was studied in two groups of mice given intravenously either 2.5 ml kg-1 Cremophor or saline followed 5 min later by 10 mg kg-1 doxorubicin. In each group three mice were sacrificed at ten time points and doxorubicin and doxorubicinol were measured in plasma by high-performance liquid chromatography (HPLC). With Cremophor present, doxorubicin AUC increased from 1420+/-440 to 2770+/-660 ng h ml(-1) (P<0.05) and doxorubicinol AUC increased from 130+/-76 to 320+/-88 ng h ml(-1) (p<0.05). Neither the terminal elimination half-lives nor the doxorubicinol-doxorubicin AUC ratio changed in the presence of Cremophor, suggesting a lack of a direct effect on drug metabolism. The possibility exists the Cremophor may change the pharmacokinetics of both paclitaxel and other drugs given concurrently.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic / blood
  • Antibiotics, Antineoplastic / pharmacokinetics*
  • Doxorubicin / analogs & derivatives*
  • Doxorubicin / blood
  • Doxorubicin / pharmacokinetics*
  • Female
  • Glycerol / analogs & derivatives*
  • Glycerol / pharmacology
  • Metabolic Clearance Rate
  • Mice
  • Mice, Inbred BALB C
  • Paclitaxel
  • Solvents
  • Time Factors


  • Antibiotics, Antineoplastic
  • Solvents
  • cremophor EL
  • Doxorubicin
  • adriamycinol
  • Paclitaxel
  • Glycerol