Human papillomavirus infection and risk of progression of epithelial abnormalities of the cervix

C B Woodman; T Rollason; J Ellis; R Tierney; S Wilson; L Young

doi:10.1038/bjc.1996.96

Human papillomavirus infection and risk of progression of epithelial abnormalities of the cervix

Br J Cancer. 1996 Feb;73(4):553-6. doi: 10.1038/bjc.1996.96.

Authors

C B Woodman¹, T Rollason, J Ellis, R Tierney, S Wilson, L Young

Affiliation

¹ Centre for Cancer Epidemiology, Christie Hospital NHS Trust, Manchester, UK.

Abstract

The polymerase chain reaction has been used to determine the presence of human papillomavirus (HPV) 16 and HPV 18 DNA sequences in archival histological material removed from a cohort of untreated women with cervical epithelial abnormalities. The detection of HPV 16 or HPV 18 DNA sequences in the initial biopsy specimen was associated with a significantly increased risk of subsequent disease progression.

Publication types

Comparative Study

MeSH terms

Cervical Intraepithelial Neoplasia / virology*
Cervix Uteri / pathology
Cervix Uteri / virology
Cohort Studies
DNA, Viral / analysis
Disease Progression
Female
Follow-Up Studies
Humans
Papillomaviridae / genetics
Papillomaviridae / isolation & purification*
Papillomavirus Infections / complications*
Papillomavirus Infections / virology
Polymerase Chain Reaction
Risk Factors
Time Factors
Tumor Virus Infections / complications*
Tumor Virus Infections / virology

Substances

DNA, Viral