Human papillomavirus infection and risk of progression of epithelial abnormalities of the cervix

Br J Cancer. 1996 Feb;73(4):553-6. doi: 10.1038/bjc.1996.96.

Abstract

The polymerase chain reaction has been used to determine the presence of human papillomavirus (HPV) 16 and HPV 18 DNA sequences in archival histological material removed from a cohort of untreated women with cervical epithelial abnormalities. The detection of HPV 16 or HPV 18 DNA sequences in the initial biopsy specimen was associated with a significantly increased risk of subsequent disease progression.

Publication types

  • Comparative Study

MeSH terms

  • Cervical Intraepithelial Neoplasia / virology*
  • Cervix Uteri / pathology
  • Cervix Uteri / virology
  • Cohort Studies
  • DNA, Viral / analysis
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Humans
  • Papillomaviridae / genetics
  • Papillomaviridae / isolation & purification*
  • Papillomavirus Infections / complications*
  • Papillomavirus Infections / virology
  • Polymerase Chain Reaction
  • Risk Factors
  • Time Factors
  • Tumor Virus Infections / complications*
  • Tumor Virus Infections / virology

Substances

  • DNA, Viral