Expression of melanocortin 1 receptor in periaqueductal gray matter

Neuroreport. 1995 Nov 13;6(16):2193-6. doi: 10.1097/00001756-199511000-00022.


The localization of the melanocortin 1 (MC1) receptor in brain was investigated by in situ hybridization and immunohistochemistry. In rat periaqueductal gray matter (PAG), a small number of cells which displayed a punctate distribution showed a specific hybridization signal for MC1 receptor mRNA, whereas other regions studied were negative. In human PAG, the immunoreactivity for MC1 receptor was detected in scattered cells. These results indicate that a restricted distribution of MC1 receptor is present in the central nervous system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization
  • Molecular Sequence Data
  • Periaqueductal Gray / chemistry*
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Corticotropin / analysis*
  • Receptors, Melanocortin


  • Receptors, Corticotropin
  • Receptors, Melanocortin