The synthetic retinoid N-(4-hydroxyphenyl) retinamide (4-HPR) exerts antiproliferative and apoptosis-inducing effects in the androgen-independent human prostatic JCA-1 cells

Biochem Mol Biol Int. 1995 Oct;37(3):499-506.


A significant reduction in JCA-1 cell proliferation was observed as a result of treatment with 4-HPR. This was accompanied by the down-regulated expression of the proliferating cell nuclear antigen PCNA, cyclins D and E, and p34cdc2. Unexpectedly, p53 and pRB was also suppressed in response to 4-HPR. A prolonged exposure to 4-HPR (6 days) promoted the appearance of non-adherent cells showing morphological features and DNA fragmentation patterns indicative of apoptosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Androgens / pharmacology*
  • Antineoplastic Agents / pharmacology*
  • Apoptosis / drug effects*
  • Cell Division / drug effects
  • Cyclins / analysis
  • Down-Regulation
  • Fenretinide / pharmacology*
  • Humans
  • Male
  • Mitogens / antagonists & inhibitors
  • Proliferating Cell Nuclear Antigen / analysis
  • Prostatic Neoplasms / drug therapy*
  • Prostatic Neoplasms / pathology
  • Tumor Cells, Cultured


  • Androgens
  • Antineoplastic Agents
  • Cyclins
  • Mitogens
  • Proliferating Cell Nuclear Antigen
  • Fenretinide