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. 1996 Mar 22;271(5256):1734-6.
doi: 10.1126/science.271.5256.1734.

Enhancement of Antitumor Immunity by CTLA-4 Blockade

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Enhancement of Antitumor Immunity by CTLA-4 Blockade

D R Leach et al. Science. .

Abstract

One reason for the poor immunogenicity of many tumors may be that they cannot provide signals for CD28-mediated costimulation necessary to fully activate T cells. It has recently become apparent that CTLA-4, a second counterreceptor for the B7 family of costimulatory molecules, is a negative regulator of T cell activation. Here, in vivo administration of antibodies to CTLA-4 resulted in the rejection of tumors, including preestablished tumors. Furthermore, this rejection resulted in immunity to a secondary exposure to tumor cells. These results suggest that blockade of the inhibitory effects of CTLA-4 can allow for, and potentiate, effective immune responses against tumor cells.

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