Replacement of DHEA in aging men and women. Potential remedial effects

Ann N Y Acad Sci. 1995 Dec 29;774:128-42. doi: 10.1111/j.1749-6632.1995.tb17377.x.


DHEA in appropriate replacement doses appears to have remedial effects with respect to its ability to induce an anabolic growth factor, increase muscle strength and lean body mass, activate immune function, and enhance quality of life in aging men and women, with no significant adverse effects. Further studies are needed to confirm and extend our current results, particularly the gender differences.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Oral
  • Adult
  • Aged
  • Aging*
  • Body Composition
  • Cross-Over Studies
  • Dehydroepiandrosterone / administration & dosage*
  • Double-Blind Method
  • Female
  • Humans
  • Immunity
  • Insulin-Like Growth Factor I / metabolism
  • Lymphocyte Activation
  • Male
  • Middle Aged
  • Muscles / physiology
  • Receptors, Interleukin-2 / metabolism


  • Receptors, Interleukin-2
  • Dehydroepiandrosterone
  • Insulin-Like Growth Factor I