Quantification of liver blood volume: comparison of ultra short TI inversion recovery echo planar imaging (ULSTIR-EPI), with dynamic 3D-gradient recalled echo imaging

Magn Reson Med. 1995 Dec;34(6):845-52. doi: 10.1002/mrm.1910340609.


An ultra-short TI inversion recovery echo-planar imaging (ULSTIR-EPI) sequence was designed to reduce the influence of water exchange on fractional tissue blood volume (BV) estimation by measurement of T1-changes induced by a gadolinium-based macromolecular contrast medium (MMCM). Fractional liver BV in rats, estimated by ULSTIR-EPI was compared for accuracy to a fast T1-weighted three-dimensional gradient-echo (3D-SPGR, 3D-spoiled gradient recalled acquisition in a steady state) sequence using an in vitro inductively coupled plasma atomic emission spectroscopy (ICP-AES) assay for BV as a standard. Liver images for fractional BV estimation were acquired in eight rats using both ULSTIR-EPI and 3D-SPGR before and after (within 3 to 12 min) intravenous bolus administration of albumin-Gd-DTPA30 (0.05 mmol Gd/kg). Whereas both MR techniques may be useful for fractional tissue BV estimation, ULSTIR-EPI offers certain advantages including greater accuracy, direct T1 maps, and minimization of transendothelial proton exchange effects. 3D-SPGR imaging offers better spatial resolution, current availability on standard clinical MR systems, and acceptable accuracy.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Albumins
  • Animals
  • Blood Volume Determination
  • Blood Volume*
  • Contrast Media
  • Echo-Planar Imaging / methods*
  • Female
  • Gadolinium DTPA*
  • Image Processing, Computer-Assisted
  • Liver / anatomy & histology
  • Liver / blood supply*
  • Magnetic Resonance Imaging / methods*
  • Organometallic Compounds
  • Pentetic Acid / analogs & derivatives
  • Rats
  • Rats, Inbred F344


  • Albumins
  • Contrast Media
  • Organometallic Compounds
  • albumin-(gadolinium-DTPA)
  • Pentetic Acid
  • Gadolinium DTPA