Serial transplantation in SCID mice of an epidermodysplasia verruciformis-associated squamous cell carcinoma without alteration of its histological and virological features

Virology. 1996 Mar 1;217(1):380-3. doi: 10.1006/viro.1996.0127.

Abstract

An epidermodysplasia verruciformis-associated squamous cell carcinoma was xenografted to a SCID mouse, and the resultant tumor was transplanted through mice for 10 generations. Histological and virological features, with replication of about a thousand copies of the papillomavirus DNA, were the same in both the original carcinoma and the transplanted tumors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carcinoma, Squamous Cell / genetics
  • Carcinoma, Squamous Cell / pathology*
  • Carcinoma, Squamous Cell / surgery
  • Carcinoma, Squamous Cell / virology
  • DNA, Neoplasm / analysis
  • DNA, Viral / analysis
  • Epidermodysplasia Verruciformis / genetics
  • Epidermodysplasia Verruciformis / pathology*
  • Epidermodysplasia Verruciformis / surgery
  • Epidermodysplasia Verruciformis / virology
  • Humans
  • Male
  • Mice
  • Mice, SCID
  • Neoplasm Transplantation*
  • Papillomaviridae / genetics
  • Papillomaviridae / physiology
  • Skin Neoplasms / genetics
  • Skin Neoplasms / pathology*
  • Skin Neoplasms / surgery
  • Skin Neoplasms / virology
  • Transplantation, Heterologous

Substances

  • DNA, Neoplasm
  • DNA, Viral